Using WiinUSoft 3.3 on Windows 10 with Wii remotes (I had to roll back from 3.4 because only the thumbstick and C button were working - mentioned in an earlier thread)
While playing multiplayer games on Steam (Ultimate Chicken Horse and others), various wii remotes will power off on their own. All of them seem to be susceptible and sometimes happen within 5 minutes of each other. When this happens, it's like the wii remote is bricked as none of the lights will blink when pressing the buttons - I have to remove the batteries and put them back in before they become responsive again.
I can't say for certainty that this is caused by WiinUSoft, but the batteries are fresh and it doesn't happen when using them on a Wii console. But with WiinUSoft + Steam, I can't seem to make it more than 10 minutes into a game before it happens.